pI: 9.0116 |
Length (AA): 163 |
MW (Da): 18450 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Ortholog group members (OG5_128246)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G72480 | lung seven transmembrane receptor-like protein |
Arabidopsis thaliana | AT2G01070 | lung seven transmembrane receptor-like protein |
Arabidopsis thaliana | AT1G61670 | lung seven transmembrane receptor domain-containing protein |
Brugia malayi | Bm1_45315 | Lung seven transmembrane receptor family protein |
Candida albicans | CaO19.1991 | similar to S. cerevisiae YHL017W |
Candida albicans | CaO19.9542 | similar to protein of unknown function |
Caenorhabditis elegans | CELE_C52B9.4 | Protein C52B9.4 |
Cryptosporidium hominis | Chro.80344 | hypothetical protein |
Cryptosporidium parvum | cgd8_2950 | cervesiae Yh1017wp/PTM1 like protein; signal peptide plus 7 pass transmembrane regions |
Dictyostelium discoideum | DDB_G0285943 | lung seven transmembrane receptor family protein |
Drosophila melanogaster | Dmel_CG17660 | CG17660 gene product from transcript CG17660-RA |
Echinococcus granulosus | EgrG_000413600 | Transmembrane receptor eukaryota |
Echinococcus multilocularis | EmuJ_000413600 | Transmembrane receptor, eukaryota |
Homo sapiens | ENSG00000103978 | transmembrane protein 87A |
Homo sapiens | ENSG00000153214 | transmembrane protein 87B |
Loa Loa (eye worm) | LOAG_10063 | hypothetical protein |
Loa Loa (eye worm) | LOAG_09361 | hypothetical protein |
Mus musculus | ENSMUSG00000033808 | transmembrane protein 87A |
Mus musculus | ENSMUSG00000014353 | transmembrane protein 87B |
Neospora caninum | NCLIV_054110 | YHL017Wp-like protein, related |
Oryza sativa | 4347168 | Os09g0439700 |
Oryza sativa | 4343895 | Os07g0614600 |
Oryza sativa | 4350693 | Os11g0546100 |
Oryza sativa | 4332753 | Os03g0334800 |
Onchocerca volvulus | OVOC8424 |
|
Plasmodium berghei | PBANKA_1431600 | serpentine receptor, putative |
Plasmodium falciparum | PF3D7_1215900 | serpentine receptor, putative |
Plasmodium knowlesi | PKNH_1435400 | serpentine receptor, putative |
Plasmodium vivax | PVX_123475 | hypothetical protein, conserved |
Plasmodium yoelii | PY02272 | hypothetical protein |
Saccharomyces cerevisiae | YKL039W | Ptm1p |
Saccharomyces cerevisiae | YHL017W | hypothetical protein |
Schmidtea mediterranea | mk4.022807.00 | |
Toxoplasma gondii | TGME49_310000 | membrane protein, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
PBANKA_1431600 | Plasmodium berghei | Dispensable | plasmo |
TGME49_310000 | Toxoplasma gondii | Probably non-essential | sidik |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.